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遺伝情報研究部門の研究業績

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2017年

総説・原著論文

Yuge K, Hara M, Okabe R, Nakamura Y, Okamura H, Nagamitsu S, Yamashita Y,  Orimoto K, Kojima M, Matsuishi T: Ghrelin improves dystonia and tremor in patients with Rett syndrome: A pilot study. J Neurol Sci, 377: 219-223, 2017. 

Kawai K, Nakashima M, Kojima M, Yamashita S, Takakura S, Shimizu M, Kubo C, Sudo N : Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients. Clin Nutr ESPEN, 17:100-104, 2017.

Mekata T, Kono T, Satoh J, Yoshida M, Mori K, Sato T, Miyazato M, Ida T : Purification and characterization of bioactive peptides RYamide and CCHamide in the kuruma shrimp Marsupenaeus japonicus. Gen Comp Endocrinol, 246:321-330, 2017.

Kono T, Ida T, Kawahara N, Watanabe F, Biswas G, Sato T, Mori K, Miyazato M : Identification and immunoregulatory function of neuromedin U (Nmu) in the Japanese pufferfish Takifugu rubripes. Dev Comp Immunol, [Epub ahead of print], 2017.

Sato T, Ida T, Kojima M : Role of biological rhythm in the performance of physical activity. J Phys Fit Sports Med, 6: 125-134, 2017. 

 

2016年

総説・原著論文

Kojima MHamamoto ASato T. Ghrelin O-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid. J Biochem, 160(4):189-194, 2016.

Kobayashi Y, Hamamoto A, Takahashi A, Saito Y : Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder. Gen Comp Endocrinol, 230-231:103-109, 2016.

濱本明恵, 蜜山聖夏, 小林勇喜, 斎藤祐見子 : 摂食受容体MCHR1におけるインターナリゼーション機構.「顕微鏡」(日本顕微鏡学会誌),  51:13-22, 2016.

濱本明恵 : 摂食関連受容体MCHR1の細胞内分子メカニズム解明. 比較内分泌学, 42:93-97, 2016.

著書

Hamamoto A, Kobayashi Y, Saito Y : MELANIN-CONCENTRATING HORMONE RECEPTOR 1 (MCHR1). Encyclopedia of Signaling Molecules, 2nd Edition. 2016. [in press]

児島将康 : 科研費申請書の赤ペン添削ハンドブック, 羊土社, p.1-327, 2016.

佐藤貴弘 : 第12章 外界の温度変化から体内の温度環境を守るしくみ -さまざまな体温調節とホルモン-(海谷啓之, 内山実 編 : ホルモンから見た生命現象と進化シリーズ, 第V巻 ホメオスタシスと適応 -恒-), 裳華房, p.197-213, 2016.

受賞

高峰譲吉賞 (第20回)」児島将康:グレリンの発見とその心血管代謝内分泌系での生理機能の研究. 日本心血管内分泌代謝学会.

優秀発表賞濱本明恵 : 摂食・情動関連受容体MCHR1を介した1次繊毛縮退機構. 第59回日本神経化学会大会.

 

2015年

総説・原著論文

Maeda T, Nakamura Y, Shiotani H, Hojo MK, Yoshii T, Ida T, Sato T, Yoshida M, Miyazato M, Kojima M, Ozaki M. Suppressive effects of dRYamides on feedingbehavior of the blowfly, Phormia regina. Zoological Lett. 2015 Dec 8;1:35.

Mifune H, Tajiri Y, Nishi Y, Hara K, Iwata S, Tokubuchi I, Mitsuzono R, YamadaK, Kojima M. Voluntary exercise contributed to an amelioration of abnormalfeeding behavior, locomotor activity and ghrelin production concomitantly with a weight reduction in high fat diet-induced obese rats. Peptides. 2015 Sep;71:49-55.

Oya M, Kitaguchi T, Harada K, Numano R, Sato T, Kojima M, Tsuboi T. Lowglucose-induced ghrelin secretion is mediated by an ATP-sensitive potassiumchannel. J Endocrinol. 2015 Jul;226(1):25-34.

Sano H, Nakamura A, Texada MJ, Truman JW, Ishimoto H, Kamikouchi A, Nibu Y,Kume K, Ida T, Kojima M. The Nutrient-Responsive Hormone CCHamide-2 ControlsGrowth by Regulating Insulin-like Peptides in the Brain of Drosophilamelanogaster. PLoS Genet. 2015 May 28;11(5):e1005209. 

Kim Y, Kim S, Kim C, Sato T, Kojima M, Park S. Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice. Endocr J. 2015;62(3):269-75.

Shiimura Y, Ohgusu H, Sato T, Kojima M. Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2. Int J Endocrinol. 2015;2015:580908. 

Ida T, Iwamoto E, Sato T, Kojima M. Identification and application of Drosophila novel bioactive peptides dRYamides. Am J Life Sci. 2015;3(3-2):3-7.

Sato T, Oishi K, Ida T, Kojima M. Physiological functions and pathology of ghrelin. Am J Life Sci. 2015;3(3-2):8-16.

著書

児島将康 : 科研費獲得の方法とコツ 改訂第4版~実例とポイントでわかる申請書の書き方と応募戦略, 羊土社, p.1-237, 2015.

児島将康 : 科学論文はこう作る!―作成ツール使いこなし術, 中外医学社, p.1-102, 2015.

 

2014年

総説・原著論文

Sato T, Ida T, Nakamura Y, Shiimura Y, Kangawa K, Kojima M. Physiological roles of ghrelin on obesity. Obes Res Clin Pract. 2014 Sep-Oct;8(5):e405-13.

Godai K, Hasegawa-Moriyama M, Kurimoto T, Saito T, Yamada T, Sato T, Kojima M, Kanmura Y. Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway. Mol Pain.  2014 Jun 14;10:36.

Kizaki J, Aoyagi K, Sato T, Kojima M, Shirouzu K. Production of ghrelin by the stomach of patients with gastric cancer. Kurume Med J. 2014;60(3-4):99-104.

Miura H, Hojo N, Takahashi R, Kikuchi M, Kojima M, Kangawa K, Hasegawa Y, Sakaguchi M. The influence of feeding pattern on changes in plasma ghrelin in the Holstein cow. J Vet Med Sci. 2014 Aug;76(8):1137-9.

Tripathy R, Kunwar PS, Sano H, Renault AD. Transcriptional regulation of Drosophila gonad formation. Dev Biol. 2014 Aug 15;392(2):193-208.

Hara M, Nishi Y, Yamashita Y, Hirata R, Takahashi S, Nagamitsu S, Hosoda H, Kangawa K, Kojima M, Matsuishi T. Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome. Brain Dev. 2014 Oct;36(9):794-800.

Li E, Kim Y, Kim S, Sato T, Kojima M, Park S. Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice. Exp Neurol. 2014 Feb;252:75-84. 

受賞

川上賞 (第30回)」佐藤貴弘:グレリンの分泌調節系およびグレリンによる体温調節系の解析. 日本神経内分泌学会.

 

2013年

総説・原著論文

Nakamura Y, Sato T, Shiimura Y, Miura Y, Kojima M. FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1. Biochem Biophys Res Commun. 2013 Nov 8;441(1):42-6.

Nishi Y, Mifune H, Yabuki A, Tajiri Y, Hirata R, Tanaka E, Hosoda H, Kangawa  K, Kojima M. Changes in Subcellular Distribution of n-Octanoyl or n-Decanoyl Ghrelin in Ghrelin-Producing Cells. Front Endocrinol (Lausanne). 2013 Jul 9;4:84.

Hasegawa-Moriyama M, Kurimoto T, Nakama M, Godai K, Kojima M, Kuwaki T, Kanmura Y. Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates inflammatory pain through the induction of heme oxygenase-1 in macrophages. Pain. 2013 Aug;154(8):1402-12.

Kojima M, Kangawa K. Ghrelin discovery: a decade after. Endocr Dev. 2013;25:1-4.

Fukumori R, Mita T, Sugino T, Hasegawa Y, Kojima M, Kangawa K, Obitsu T, Taniguchi K. Effects of intravenous ghrelin injection on plasma growth hormone, insulin and glucose concentrations in calves at weaning. Anim Sci J. 2013 Apr;84(4):310-5.

Li E, Chung H, Kim Y, Kim DH, Ryu JH, Sato T, Kojima M, Park S. Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr J. 2013;60(6):781-9. 

著書

児島将康 : 科研費獲得の方法とコツ 改訂第3版~実例とポイントでわかる申請書の書き方と応募戦略, 羊土社, p.1-221, 2013.

 

2012年

総説・原著論文

Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M. Isolation of the bioactive peptides CCHamide-1and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors. Front Endocrinol (Lausanne). 2012 Dec31;3:177.

Hashinaga T, Wada N, Otabe S, Yuan X, Kurita Y, Kakino S, Tanaka K, Sato T, Kojima M, Ohki T, Nakayama H, Egashira T, Tajiri Y, Yamada K. Modulation byadiponectin of circadian clock rhythmicity in model mice for metabolic syndrome. Endocr J. 2013;60(4):483-92.

Mori M, Mori K, Ida T, Sato T, Kojima M, Miyazato M, Kangawa K. Differentdistribution of neuromedin S and its mRNA in the rat brain: NMS peptide ispresent not only in the hypothalamus as the mRNA, but also in the brainstem. Front Endocrinol (Lausanne). 2012 Dec 3;3:152.

Kojima M, Kangawa K. Methods in Enzymology. Ghrelin. Preface. Methods Enzymol. 2012;514:xxi.

Nishi Y, Mifune H, Kojima M. Ghrelin acylation by ingestion of medium-chainfatty acids. Methods Enzymol. 2012;514:303-15.

Ohgusu H, Takahashi T, Kojima M. Enzymatic characterization of GOAT, ghrelin O-acyltransferase. Methods Enzymol. 2012;514:147-63.

Sato T, Kojima M. High-performance liquid chromatography analysis ofhypothalamic ghrelin. Methods Enzymol. 2012;514:101-12.

Kojima M, Hosoda H, Kangawa K. Purification of rat and human ghrelins. Methods Enzymol. 2012;514:45-61.

Hamada N, Nishi Y, Tajiri Y, Setoyama K, Kamimura R, Miyahara K, Nuruki N, Hosoda H, Kangawa K, Kojima M, Mifune H. Disrupted regulation of ghrelinproduction under antihypertensive treatment in spontaneously hypertensive rats. Circ J. 2012;76(6):1423-9.

Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA. The neuropeptide neuromedin U promotesautoantibody-mediated arthritis. Arthritis Res Ther. 2012 Feb 7;14(1):R29.

Sato T, Nakamura Y, Shiimura Y, Ohgusu H, Kangawa K, Kojima M. Structure,regulation and function of ghrelin. J Biochem. 2012 Feb;151(2):119-28. 
 

2011年

総説・原著論文

Kojima M, Kangawa K. The discovery of ghrelin: with a little luck and great passion. Preface. Peptides. 2011 Nov;32(11):2153-4.

Mifune H, Nishi Y, Tajiri Y, Masuyama T, Hosoda H, Kangawa K, Kojima M. Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats. Metabolism. 2012 Apr;61(4):491-5.

Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagaye K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M. Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila. Biochem Biophys Res Commun. 2011 Oct 14;414(1):44-8.

Nishi Y, Yoh J, Hiejima H, Kojima M. Structures and molecular forms of the ghrelin-family peptides. Peptides. 2011 Nov;32(11):2175-82.

Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T. Ghrelin levels are reduced in Rett syndrome patients with eating difficulties. Int J Dev Neurosci. 2011 Dec;29(8):899-902.

Fukumori R, Yokotani A, Sugino T, Itoh F, Kushibiki S, Shingu H, Moriya N, Hasegawa Y, Kojima M, Kangawa K, Obitsu T, Taniguchi K. Effects of amino acids infused into the vein on ghrelin-induced GH, insulin and glucagon secretion in lactating cows. Anim Sci J. 2011 Apr;82(2):267-73.

Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozaki M, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M. Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila. Biochem Biophys Res Commun. 2011 Jul 15;410(4):872-7.

Yoh J, Nishi Y, Hosoda H, Tajiri Y, Yamada K, Yanase T, Doi R, Yonemoto K, Kangawa K, Kojima M, Tanaka E, Kusukawa J. Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics. Regul Pept. 2011 Feb 25;167(1):140-8.

Nanjo Y, Adachi H, Hirai Y, Enomoto M, Fukami A, Otsuka M, Yoshikawa K, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Murayama K, Yasukawa H, Kojima M, Imaizumi T. Factors associated with plasma ghrelin level in Japanese general population. Clin Endocrinol (Oxf). 2011 Apr;74(4):453-8. 

著書

児島将康 : 科研費獲得の方法とコツ 改訂第2版, 羊土社, p.1-190, 2011.

 

*2011年度以降のみ掲載しています.

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