2023

原著論文

Hoshino R, Sano H, Yoshinari Y, Nishimura T, Niwa R. Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila. Sci Adv, in press, 2023.

Yazawa T, Islam MS, Imamichi Y, Watanabe H, Yaegashi K, Ida T, Sato T, Matsuzaki S, Kitano T, Umezawa A, Muranishi Y. Comparison of Placental HSD17B1 Expression and its Regulation in Various Mammalian Species. Animals, 13: 622, 2023

2022

総説

Sato T, Ida T, Shiimura Y, Matsui K., Oishi K, Kojima M. Insights into the regulation of offspring growth by maternally derived ghrelin. Front Endocrinol, 13: 852636-852636, 2022.

原著論文

Yamagata N, Imanishi Y, Wu Hongyang, Kondo S, Sano H, Tanimoto H. Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory. Front Behav Neurosci, 16: 986064, 2022.

Sano H, Nakamura A, Yamane M, Niwa H, Nishimura T, Takemoto K, Ishiguro K, Aoki H, Kato Y, Kojima M. The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. PLoS Biol, 20: e3001678, 2022.

商業誌

佐藤貴弘, 井田隆徳, 椎村祐樹, 児島将康. 臓器連関のメディエーター-生理活性ペプチド-. 循環器内科 92: 668-674, 2022.

2021

原著論文

Sato T, Oishi K, Koga D, Ida T, Sakai Y, Kangawa K, Kojima M. Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition. Sci Rep 11: 17954-17954, 2021.

Islam MS, Uwada J, Hayashi J, Kikuya K, Muranishi Y, Watanabe H, Yaegashi K, Hasegawa K, Ida T, Sato T, Imamichi Y, Kitano K, Miyashiro Y, Khan RI, Takahashi S, Umezawa A, Suzuki N, Sekiguchi T, Yazawa T. Analyses of Molecular Characteristics and Enzymatic Activities of Ovine HSD17B3. Animals, 11: 2876-2876, 2021.

Sakai N, Ohno H, Yoshida M, Iwamoto E, Kurogi A, Jiang D, Sato T, Miyazato M, Kojima M, Kato J, Ida T. Characterization of putative tachykinin peptides in Caenorhabditis elegans. Biochem Biophys Res Commun, 559: 197-202, 2021.

Yazawa T, Inaba H, Imamichi Y, Sekiguchi T, Uwada J, Islam MS, Orisaka M, Mikami D, Ida T, Sato T, Miyashiro Y, Takahashi S, Khan RI, Suzuki N, Umezawa A, Kitano T. Profiles of 5α-Reduced Androgens in humans and eels: 5α-dihydrotestosterone and 11-ketodihydrotestosterone are active androgens produced in eel gonads. Front Endocrinol, 12: 657360-657360, 2021.

Maeda S, Shiimura Y, Asada H, Hirata H, Luo F, Nango E, Tanaka N, Toyomoto M, Inoue A, Aoki J, Iwata S, Hagiwara M. Endogenous antagonist-bound S1PR3 structure reveals determinants of G protein-subtype bias. Sci adv, 24: eabf5325, 2021.

Yazawa T, Sato T, Nemoto T, Nagata S, Imamichi Y, Kitano T, Sekiguchi T, Uwada J, Islam MS, Mikami D, Nakajima I, Takahashi S, Khan RI, Suzuki N, Umezawa A, Ida T. 11-Ketotestosterone is a major androgen produced in porcine adrenal glands and testes. J Steroid Biochem Mol Biol, 210: 105847-105847, 2021.

和文総説

佐野浩子. ショウジョウバエの環境応答を支える栄養応答性ホルモン. 基礎老化研究45: 31-36, 2021.

商業誌

佐藤貴弘, 椎村祐樹, 梶谷宇, 岩田想, 児島将康. 脳とからだ IV.内分泌系と脳の相互作用 食欲制御のコンダクター:グレリン. 生体の科学 72: 485-488, 2021.

2020

総説・原著論文

Shiimura Y, Iwata S, Kojima M. Protein Crystallography: Crystal structure of an antagonist-bound ghrelin receptor. Spring-8/SACLA Research Frontiers 18-19, 2020.

Shiimura Y, Horita S, Hamamoto A, Asada H, Hirata K, Tanaka M, Mori K, Uemura T, Kobayashi T, Iwata S, Kojima M：Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode. Nat Commun. 11(1): 4160, 2020.
pubmed

Muta H, Sugita Y, Furuta T, Shiimura Y, Ohshima K, Nakashima K, Sato K, Morika M, Abe H, Nozawa T, Fujii Y, Kakita A. Expression of the ghrelin/ growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas. Neuropathology, [Epub ahead of print], 2020.
pubmed

Yazawa T, Imamichi Y, Uwada J, Sekiguchi T, Mikami D, Kitano T, Ida T, Sato T, Nemoto T, Nagata S, Islam Khan MR, Takahashi S, Ushikubi F, Suzuki N, Umezawa A, Taniguchi T. Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation. J Steroid Biochem Mol Biol, 196: 105493, 2020.
pubmed

Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H,, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S. The crystal structure of angiotensin II type 2 receptor with endogenous peptide hormone. Structure 28: 418-425, 2020.
pubmed

Sato T, Oishi K, Ida T, Kojima M. Suppressive effect of ghrelin on nicotine-induced clock gene expression in the mouse pancreas. Endocr J, 67: 73-80, 2020.
pubmed

Mifune H, Tajiri Y, Sakai Y, Kawahara Y, Hara K, Sato T, Nishi Y, Nishi A, Mitsuzono R, Kakuma T, Kojima M. Voluntary exercise is motivated by ghrelin, possible related to the central reward circuit. J Endocrinol, 244: 123-132, 2020.
pubmed

2019

総説・原著論文

Yazawa T, Uwada J, Imamichi Y, Mikami D, Sato T, Islam Khan MR, Sayful Islam M, Taniguchi T. Nicotinic acetylcholine receptor-mediated signaling pathways in pluripotent stem cells. Am J Biomed Sci Res 6: 361-363, 2019.

Sato T, Nemoto T, Hasegawa K, Ida T, Kojima M. A new action of peptide hormones for survival in a low-nutrient environment. Endocr J, 66: 943-952, 2019.

Suzuki H, Ataka K, Asakawa A, Cheng KC, Ushikai M, Iwai H, Yagi T, Arai T, Yahiro K, Yamamoto K, Yokoyama Y, Kojima M, Yada T, Hirayama T, Nakamura N, Inui A. Helicobacter pylori vacuolating cytotoxin a causes anorexia and anxiety via hypothalamic urocortin 1 in mice. Sci Rep, 9: 6011, 2019.

Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. : Ligand binding to human prostaglandin E receptor EP(4) at the lipid-bilayer interface. Nat Chem Biol, 15: 18-26, 2019.

商業誌

佐藤貴弘，井田隆徳，関口俊男，中町智哉，児島将康：第3章　臓器連環による生体の動的恒常性「2 消化管関連ペプチドが拓く恒常性フロンティア」（春日雅人 編 :臓器連環による生体恒常性の破綻と疾患 , 羊土社), 実験医学増刊号 37(7): 129-135, 2019.

受賞

「松尾研究奨励賞 (第4回)」椎村祐樹 : グレリン受容体のX線結晶構造解析. 第15回GPCR研究会.

「日本内分泌学会 研究奨励賞 (第39回) 」佐藤貴弘 : 低栄養環境下におけるエネルギー保持機構の解明. 第92回日本内分泌学会学術総会.

2018

総説・原著論文

Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S. : Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nat Struct Mol Biol, 25: 570-576, 2018.

Ishimoto H, Sano H. : Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila. J Vis Exp, 2018 Jun 2;(136).

Yanagi S, Sato T, Kangawa K, Nakazato M.：The homeostaitc force of ghrelin. Cell Metab, 27: 786-804, 2018.

商業誌

椎村祐樹，佐藤貴弘，児島将康：IV.細胞外での分子修飾　オクタノイル化（医学書院 編 : [増大特集]タンパク質・核酸の分子修飾), 生体の科学 69: 506-507, 2018.

著書

児島将康 : 科研費獲得の方法とコツ 改訂第6版～実例とポイントでわかる申請書の書き方と応募戦略, 羊土社, p.1-277, 2018.

受賞

「松尾賞 (第3回)」児島将康 : グレリン研究のこれから. 第36回内分泌代謝学サマーセミナー.

「日本内分泌学会 若手研究奨励賞 (第19回) 」椎村祐樹 : グレリン受容体の結晶構造解析による活性型グレリン認識機構の解明. 第91回日本内分泌学会学術総会.

2017

総説・原著論文

Ohno H, Yoshida M, Sato T, Kato J, Miyazato M, Kojima M, Ida T, Iino Y. Luqin-like RYamide peptides regulate food-evoked responses in C. elegans. Elife, pii: e28877, 2017.

Yuge K, Hara M, Okabe R, Nakamura Y, Okamura H, Nagamitsu S, Yamashita Y, Orimoto K, Kojima M, Matsuishi T: Ghrelin improves dystonia and tremor in patients with Rett syndrome: A pilot study. J Neurol Sci, 377: 219-223, 2017.

Kawai K, Nakashima M, Kojima M, Yamashita S, Takakura S, Shimizu M, Kubo C, Sudo N : Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients. Clin Nutr ESPEN, 17: 100-104, 2017.

Mekata T, Kono T, Satoh J, Yoshida M, Mori K, Sato T, Miyazato M, Ida T : Purification and characterization of bioactive peptides RYamide and CCHamide in the kuruma shrimp Marsupenaeus japonicus. Gen Comp Endocrinol, 246: 321-330, 2017.

Kono T, Ida T, Kawahara N, Watanabe F, Biswas G, Sato T, Mori K, Miyazato M : Identification and immunoregulatory function of neuromedin U (Nmu) in the Japanese pufferfish Takifugu rubripes. Dev Comp Immunol, 73: 246-256, 2017.

Sato T, Ida T, Kojima M : Role of biological rhythm in the performance of physical activity. J Phys Fit Sports Med, 6: 125-134, 2017.

著書

児島将康 : 科研費獲得の方法とコツ 改訂第5版～実例とポイントでわかる申請書の書き方と応募戦略, 羊土社, p.1-252, 2017.

2015

総説・原著論文

Maeda T, Nakamura Y, Shiotani H, Hojo MK, Yoshii T, Ida T, Sato T, Yoshida M, Miyazato M, Kojima M, Ozaki M. Suppressive effects of dRYamides on feedingbehavior of the blowfly, Phormia regina. Zoological Lett. 2015 Dec 8;1:35.

Mifune H, Tajiri Y, Nishi Y, Hara K, Iwata S, Tokubuchi I, Mitsuzono R, YamadaK, Kojima M. Voluntary exercise contributed to an amelioration of abnormalfeeding behavior, locomotor activity and ghrelin production concomitantly with a weight reduction in high fat diet-induced obese rats. Peptides. 2015 Sep;71:49-55.

Oya M, Kitaguchi T, Harada K, Numano R, Sato T, Kojima M, Tsuboi T. Lowglucose-induced ghrelin secretion is mediated by an ATP-sensitive potassiumchannel. J Endocrinol. 2015 Jul;226(1):25-34.

Sano H, Nakamura A, Texada MJ, Truman JW, Ishimoto H, Kamikouchi A, Nibu Y,Kume K, Ida T, Kojima M. The Nutrient-Responsive Hormone CCHamide-2 ControlsGrowth by Regulating Insulin-like Peptides in the Brain of Drosophilamelanogaster. PLoS Genet. 2015 May 28;11(5):e1005209.

Kim Y, Kim S, Kim C, Sato T, Kojima M, Park S. Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice. Endocr J. 2015;62(3):269-75.

Shiimura Y, Ohgusu H, Sato T, Kojima M. Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2. Int J Endocrinol. 2015;2015:580908.

Ida T, Iwamoto E, Sato T, Kojima M. Identification and application of Drosophila novel bioactive peptides dRYamides. Am J Life Sci. 2015;3(3-2):3-7.

Sato T, Oishi K, Ida T, Kojima M. Physiological functions and pathology of ghrelin. Am J Life Sci. 2015;3(3-2):8-16.

著書

児島将康 : 科研費獲得の方法とコツ 改訂第4版～実例とポイントでわかる申請書の書き方と応募戦略, 羊土社, p.1-237, 2015.

児島将康 : 科学論文はこう作る!―作成ツール使いこなし術, 中外医学社, p.1-102, 2015.

2014

総説・原著論文

Sato T, Ida T, Nakamura Y, Shiimura Y, Kangawa K, Kojima M. Physiological roles of ghrelin on obesity. Obes Res Clin Pract. 2014 Sep-Oct;8(5):e405-13.

Godai K, Hasegawa-Moriyama M, Kurimoto T, Saito T, Yamada T, Sato T, Kojima M, Kanmura Y. Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway. Mol Pain. 2014 Jun 14;10:36.

Kizaki J, Aoyagi K, Sato T, Kojima M, Shirouzu K. Production of ghrelin by the stomach of patients with gastric cancer. Kurume Med J. 2014;60(3-4):99-104.

Miura H, Hojo N, Takahashi R, Kikuchi M, Kojima M, Kangawa K, Hasegawa Y, Sakaguchi M. The influence of feeding pattern on changes in plasma ghrelin in the Holstein cow. J Vet Med Sci. 2014 Aug;76(8):1137-9.

Tripathy R, Kunwar PS, Sano H, Renault AD. Transcriptional regulation of Drosophila gonad formation. Dev Biol. 2014 Aug 15;392(2):193-208.

Hara M, Nishi Y, Yamashita Y, Hirata R, Takahashi S, Nagamitsu S, Hosoda H, Kangawa K, Kojima M, Matsuishi T. Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome. Brain Dev. 2014 Oct;36(9):794-800.

Li E, Kim Y, Kim S, Sato T, Kojima M, Park S. Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice. Exp Neurol. 2014 Feb;252:75-84.

受賞

「「日本神経内分泌学会 川上」 (第30回)」佐藤貴弘：グレリンの分泌調節系およびグレリンによる体温調節系の解析. 日本神経内分泌学会.

2013

総説・原著論文

Nakamura Y, Sato T, Shiimura Y, Miura Y, Kojima M. FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1. Biochem Biophys Res Commun. 2013 Nov 8;441(1):42-6.

Nishi Y, Mifune H, Yabuki A, Tajiri Y, Hirata R, Tanaka E, Hosoda H, Kangawa K, Kojima M. Changes in Subcellular Distribution of n-Octanoyl or n-Decanoyl Ghrelin in Ghrelin-Producing Cells. Front Endocrinol (Lausanne). 2013 Jul 9;4:84.

Hasegawa-Moriyama M, Kurimoto T, Nakama M, Godai K, Kojima M, Kuwaki T, Kanmura Y. Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates inflammatory pain through the induction of heme oxygenase-1 in macrophages. Pain. 2013 Aug;154(8):1402-12.

Kojima M, Kangawa K. Ghrelin discovery: a decade after. Endocr Dev. 2013;25:1-4.

Fukumori R, Mita T, Sugino T, Hasegawa Y, Kojima M, Kangawa K, Obitsu T, Taniguchi K. Effects of intravenous ghrelin injection on plasma growth hormone, insulin and glucose concentrations in calves at weaning. Anim Sci J. 2013 Apr;84(4):310-5.

Li E, Chung H, Kim Y, Kim DH, Ryu JH, Sato T, Kojima M, Park S. Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr J. 2013;60(6):781-9.

著書

児島将康 : 科研費獲得の方法とコツ 改訂第3版～実例とポイントでわかる申請書の書き方と応募戦略, 羊土社, p.1-221, 2013.

2012

総説・原著論文

Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M. Isolation of the bioactive peptides CCHamide-1and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors. Front Endocrinol (Lausanne). 2012 Dec31;3:177.

Hashinaga T, Wada N, Otabe S, Yuan X, Kurita Y, Kakino S, Tanaka K, Sato T, Kojima M, Ohki T, Nakayama H, Egashira T, Tajiri Y, Yamada K. Modulation byadiponectin of circadian clock rhythmicity in model mice for metabolic syndrome. Endocr J. 2013;60(4):483-92.

Mori M, Mori K, Ida T, Sato T, Kojima M, Miyazato M, Kangawa K. Differentdistribution of neuromedin S and its mRNA in the rat brain: NMS peptide ispresent not only in the hypothalamus as the mRNA, but also in the brainstem. Front Endocrinol (Lausanne). 2012 Dec 3;3:152.

Kojima M, Kangawa K. Methods in Enzymology. Ghrelin. Preface. Methods Enzymol. 2012;514:xxi.

Nishi Y, Mifune H, Kojima M. Ghrelin acylation by ingestion of medium-chainfatty acids. Methods Enzymol. 2012;514:303-15.

Ohgusu H, Takahashi T, Kojima M. Enzymatic characterization of GOAT, ghrelin O-acyltransferase. Methods Enzymol. 2012;514:147-63.

Sato T, Kojima M. High-performance liquid chromatography analysis ofhypothalamic ghrelin. Methods Enzymol. 2012;514:101-12.

Kojima M, Hosoda H, Kangawa K. Purification of rat and human ghrelins. Methods Enzymol. 2012;514:45-61.

Hamada N, Nishi Y, Tajiri Y, Setoyama K, Kamimura R, Miyahara K, Nuruki N, Hosoda H, Kangawa K, Kojima M, Mifune H. Disrupted regulation of ghrelinproduction under antihypertensive treatment in spontaneously hypertensive rats. Circ J. 2012;76(6):1423-9.

Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA. The neuropeptide neuromedin U promotesautoantibody-mediated arthritis. Arthritis Res Ther. 2012 Feb 7;14(1):R29.

Sato T, Nakamura Y, Shiimura Y, Ohgusu H, Kangawa K, Kojima M. Structure,regulation and function of ghrelin. J Biochem. 2012 Feb;151(2):119-28.

2011

総説・原著論文

Kojima M, Kangawa K. The discovery of ghrelin: with a little luck and great passion. Preface. Peptides. 2011 Nov;32(11):2153-4.

Mifune H, Nishi Y, Tajiri Y, Masuyama T, Hosoda H, Kangawa K, Kojima M. Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats. Metabolism. 2012 Apr;61(4):491-5.

Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagaye K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M. Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila. Biochem Biophys Res Commun. 2011 Oct 14;414(1):44-8.

Nishi Y, Yoh J, Hiejima H, Kojima M. Structures and molecular forms of the ghrelin-family peptides. Peptides. 2011 Nov;32(11):2175-82.

Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T. Ghrelin levels are reduced in Rett syndrome patients with eating difficulties. Int J Dev Neurosci. 2011 Dec;29(8):899-902.

Fukumori R, Yokotani A, Sugino T, Itoh F, Kushibiki S, Shingu H, Moriya N, Hasegawa Y, Kojima M, Kangawa K, Obitsu T, Taniguchi K. Effects of amino acids infused into the vein on ghrelin-induced GH, insulin and glucagon secretion in lactating cows. Anim Sci J. 2011 Apr;82(2):267-73.

Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozaki M, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M. Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila. Biochem Biophys Res Commun. 2011 Jul 15;410(4):872-7.

Yoh J, Nishi Y, Hosoda H, Tajiri Y, Yamada K, Yanase T, Doi R, Yonemoto K, Kangawa K, Kojima M, Tanaka E, Kusukawa J. Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics. Regul Pept. 2011 Feb 25;167(1):140-8.

Nanjo Y, Adachi H, Hirai Y, Enomoto M, Fukami A, Otsuka M, Yoshikawa K, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Murayama K, Yasukawa H, Kojima M, Imaizumi T. Factors associated with plasma ghrelin level in Japanese general population. Clin Endocrinol (Oxf). 2011 Apr;74(4):453-8.

著書

児島将康 : 科研費獲得の方法とコツ 改訂第2版, 羊土社, p.1-190, 2011.